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A Phase 2 trial of the liposomal DACH platinum L-NDDP in patients with therapy-refractory advanced colorectal cancer

✍ Scribed by Tomislav Dragovich; David Mendelson; Sandra Kurtin; Kelly Richardson; Daniel Von Hoff; Axel Hoos

Publisher: Springer
Year: 2006
Tongue: English
Weight: 302 KB
Volume: 58
Category: Article
ISSN: 0344-5704
DOI: 10.1007/s00280-006-0235-4

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## Background: Topotecan is a new antineoplastic agent with a broad spectrum of activity. the purpose of this phase i trial was to define the maximum tolerated dose of topotecan when added to the widely used combination of paclitaxel and carboplatin. ## Methods: Patients with advanced cancer that