## Abstract ## BACKGROUND: __nab__‐Paclitaxel (ABI‐007, Abraxane), a 130‐nM, albumin‐bound (__nab__) particle form of Cremophor‐free paclitaxel, is approved for metastatic breast cancer. In the current study, the efficacy and safety of __nab__‐paclitaxel were evaluated in previously treated and ch
A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma
✍ Scribed by Ahmad A. Tarhini; Michael Millward; Paul Mainwaring; Richard Kefford; Ted Logan; Anna Pavlick; Steven J. Kathman; Kevin H. Laubscher; Mohammed M. Dar; John M. Kirkwood
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 140 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0008-543X
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The authors tested a biotherapy regimen involving recombinant interferon-␣-2a (rIFN-␣-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. ## METH
## Background: The objective of the current study was to evaluate the response rate, survival, and toxicity of treatment with cisplatin and high dose intravenous continuous infusion interleukin-2 (il-2) with or without interferon-alpha-2a (ifn) in patients with metastatic melanoma. ## Methods: On