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A phase 1b, open-label study of trebananib in combination with paclitaxel and carboplatin in patients with ovarian cancer receiving interval or primary debulking surgery

✍ Scribed by Vergote, I.; Oaknin, A.; Baurain, J.-F.; Ananda, S.; Wong, S.; Su, X.; Wu, B.; Zhong, Z.; Warner, D.; Casado, A.


Book ID
126876678
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
453 KB
Volume
50
Category
Article
ISSN
0959-8049

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## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c