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A Phase 1 Study of the Proteasome Inhibitor Bortezomib in Pediatric Patients with Refractory Leukemia: a Children's Oncology Group Study

โœ Scribed by Horton, T. M.; Pati, D.; Plon, S. E.; Thompson, P. A.; Bomgaars, L. R.; Adamson, P. C.; Ingle, A. M.; Wright, J.; Brockman, A. H.; Paton, M.; Blaney, S. M.


Book ID
121758325
Publisher
American Association for Cancer Research
Year
2007
Tongue
English
Weight
308 KB
Volume
13
Category
Article
ISSN
1078-0432

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โœ Bell, Beverly A. ;Chang, Myron N. ;Weinstein, Howard J. ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 106 KB

## Abstract ## Background Homoharringtonine (HHT) is a plant alkaloid that is derived from a Chinese evergreen tree. Its mechanism of action is thought to be by inhibition of protein, DNA, and RNA synthesis by inhibition of chain initiation. The treatment of acute myelogenous leukemia (AML) in chi