Comparison of a new orally potent tripep
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A. Kiriyama; T. Mimoto; S. Kisanuki; Y. Kiso; K. Takada
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Article
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1993
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John Wiley and Sons
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English
⚖ 549 KB
## Abstract Recently, a series of KNI compounds such as KNI‐227 and KNI‐272 has been synthesized and shows potent and selective HIV‐1 protease inhibitory activity __in vitro__. In this study, we developed an HPLC assay system for KNI‐227 and KNI‐272 in rat plasma and examined the pharmacokinetic ch