A persistent adenovirus type 1 infection in synovial tissue from an immunodeficient patient with chronic, rheumatoid-like polyarthritis
✍ Scribed by Kevin J. Fraser; Barry J. Clarris; Kenneth D. Muirden; J. Robert E. Fraser; Ian Jack
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 569 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Microbiologic studies of patients with rheumatoid arthritis (RA) have failed to establish a causal link with any specific infective agent, though most of the evidence points to viruses rather than prokaryotes. On several occasions, virus-like particles have been detected in rheumatoid synovial tissue, using electron microscopy (1-3). However, the only successful isolations of live viruses reported so far have involved unrelated species, namely, cytomegalovirus (4) and parvovirus (5). These findings could reflect opportunistic colonization, but it is possible that more than one agent could initiate the pathogenesis of RA, in which case either or both of these viruses could qualify as potential causative agents.
In this report, we describe the isolation of another virus from arthritic synovial tissue-a human adenovirus that, hitherto, has been associated only with respiratory tract infections. The patient presented an unusual combination of chronic, erosive, rheuma-From the