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A peptide fraction from factor VIII reduces PKC activity in cultured endothelial cells

✍ Scribed by Luigia Pazzagli; Cristina Cecchi; Gianni Cappugi; Roberta Catalani; Marco Bertini; Pierre Jollés; Giampietro Ramponi

Book ID: 117175418
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 692 KB
Volume: 62
Category: Article
ISSN: 0024-3205
DOI: 10.1016/s0024-3205(97)01185-5

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## Abstract The development of autoantibodies against factor VIII represents one of the major complications in the treatment of hemophilia A patients. We have employed a novel library system to obtain peptides that specifically neutralize the interaction between factor VIII and these inhibitors. Th