A Peptide Corresponding to Residues Asp177 to Asn208 of Human Cyclin A Forms an α-Helix
✍ Scribed by Jing-Song Fan; Heung-Chin Cheng; Mingjie Zhang
- Book ID
- 115583098
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 176 KB
- Volume
- 253
- Category
- Article
- ISSN
- 0006-291X
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## Synopsis An estimation of the thermodynamic effects of a charged random coil, which is attached either to the Nor C-terminus of polyalanine, upon a-helix stability is attempted. A temperature induced helix-coil transition of Ala,Lys,Phe and Lys,Ala,Phe was studied under various conditions of sa
## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several ‘spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations