A pathway of coagulation on endothelial cells

✍ Scribed by Peter P. Nawroth; David M. Stern

• Book ID: 102878565
• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 749 KB
• Volume: 28
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/jcb.240280403

✦ Synopsis

Although the endothelial cell is considered antithrombogenic, endothelium has recently been shown to participate in procoagulant reactions. Factor IX bound to specific endothelial cell sites can be activated by the intrinsic and extrinsic pathways of coagulation. Perturbation of endothelium results in induction of tissue factor which promotes factor VI1,-mediated activation of factors IX and X, thus initiating procoagulant events on the endothelial surface. Cell bound factor IX,, in the presence of factor VIII, promotes activation of factor X. The factor X, formed can interact with endothelial cell factor V/V,, resulting in prothrombin activation. Thrombin then cleaves fibrinogen and a fibrin clot closely associated with the endothelial cell forms. The perturbed endothelial cell thus provides a focus of localized procoagulant events. This model suggests a simple endothelialcell-dependent mechanism for initiation of coagulation at the site of an injured or pathological vessel.