A partial area difference analysis for estimating elimination rate constants and distribution volumes of metabolites

Area-based estimation of the initial vol

Area-based estimation of the initial volume of distribution and elimination rate constant following intravenous bolus injection

✍ Soo Peang Khor; Stephen L. Johnson; Michael Mayersohn 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 758 KB

We evaluate here an area term, the area under the rate of change of concentration-time curve (AURC), which allows the determination of the initial or central volume of distribution (V1). It has previously been shown that AURC is equal to the sum of the coefficients of a multiexponential equation and