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A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis

✍ Scribed by Sambandamurthy, Vasan K.; Wang, Xiaojuan; Chen, Bing; Russell, Robert G.; Derrick, Steven; Collins, Frank M.; Morris, Sheldon L.; Jacobs, William R.


Book ID
109933198
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
349 KB
Volume
8
Category
Article
ISSN
1078-8956

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## Abstract Definition of protective immunity induced by effective vaccines is important for the design of new pathogen control strategies. Inactivation of the PhoP response‐regulator in __Mycobacterium tuberculosis__ results in a highly attenuated strain that demonstrates impressive protective eff