A Palladium(II)-Catalyzed Synthesis of Spiroacetals through a One-Pot Multicomponent Cascade Reaction

✍ Scribed by José Barluenga; Abraham Mendoza; Félix Rodríguez; Francisco J. Fañanás

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 270 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200805519

✦ Synopsis

Abstract

Functionalized spiroacetals have been easily prepared in a one‐pot three‐component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen‐substituted spiroacetals can be obtained by using orthoesters as the third component.magnified image