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A Pair of Phenylalanine Residues on the S4 and S5 Segments Create a Physical and Energy Barrier for the Voltage Sensor in KCNQ1/KCNE1 Channel

โœ Scribed by Nakajo, Koichi; Kubo, Yoshihiro

Book ID
122285897
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
48 KB
Volume
106
Category
Article
ISSN
0006-3495

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๐Ÿ“‚ Article ๐Ÿ“… 1907 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 451 KB
1H-1,3-Diazepines, 5H-1,3-diazepines, 1,
1H-1,3-Diazepines, 5H-1,3-diazepines, 1,3-diazepinones, and 2,4-diazabicyclo[3.2.0]heptenesPreliminary reports on parts of this work have been published in ref 1. This paper is Diazepines, Part 3. For Part 2, see ref 2.,Electronic supplementary information (ESI) available: NMR spectra of 4a, 4c, 19v ? 20, 19a ? 25a, and 19g ? 25g (Fig. S1?S6), Arrhenius and Eyring plots for H-exchange in 4b,c (Fig. S7), views of the X-ray crystal structures of compounds 26 and 22bB (Fig. S8?S9), bond lengths and angles for compounds 4k, 22bB and 26, preparative procedures and characterization data for all compounds not described in the Experimental section, and computational data (Cartesian coordinates, absolute energies, IR, 1H and 13C NMR) for 20a?c, 21a?b, 22aA?F and 22aB dimer. See http://www.rsc.org/suppdata/ob/b3/b317099c/
โœ Reisinger, Ales; Koch, Rainer; Bernhardt, Paul V.; Wentrup, Curt ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Royal Society of Chemistry ๐ŸŒ English โš– 496 KB