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A One-Pot Total Synthesis of Crambin

✍ Scribed by Duhee Bang; Stephen B. H. Kent

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
181 KB
Volume
43
Category
Article
ISSN
0044-8249

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✦ Synopsis

Crambin (Figure 1) is a small protein isolated from the plant Crambe abyssinica that has no known biological function. [1,2] It contains three disulfide bonds, an a-helix, a b-sheet, and a reverse turn-all features typical of a globular protein molecule-and for that reason crambin has been studied extensively as a model. Ultrahigh resolution (0.54 ) structures have been obtained by X-ray crystallography. [3,4] Also,

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