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A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

✍ Scribed by Nathalie Ollivier; Dr. Jérôme Vicogne; Aurélie Vallin; Hervé Drobecq; Rémi Desmet; Ouafâa El Mahdi; Bérénice Leclercq; Dr. Gautier Goormachtigh; Dr. Véronique Fafeur; Dr. Oleg Melnyk

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 613 KB
Volume: 51
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.201105837

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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Protein synthesis by native chemical ligation has been an effective approach for the synthesis of proteins of moderate size. The utility of this approach for protein synthesis is demonstrated by the synthesis of a transcription factor, Zif 268 that contains three zinc finger domains. This synthesis