𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A nuclear magnetic resonance investigation of the upper airways in ferrets. i. effects of histamine and methacholine

✍ Scribed by Nicholas V. Reo; Jeanne K. C. Barnett; Thomas A. Neubecker; Marise E. Alexander; Carol M. Goecke

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
810 KB
Volume
27
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Alterations induced in the upper airways of ferrets by intranasal provocation with methacholine (MC) and histamine (HS) were monitored using proton magnetic resonance imaging (MRI) and spin‐spin relaxation rate (R~2~) measurements. Both MC and HS cause a significant increase in the MRI signal intensity and a decrease in R~2~ in the nasal turbinates. A dose‐dependent response is observed for 20 to 315 nmol of HS, with a maximum increase in intensity of ca. 50% occurring above 80 nmol. A single unilateral challenge with MC yields a 62 ± 3% increase in intensity. Control animals (saline‐treated) show little change in image intensity. MC and HS cause decreases in the proton R~2~ by −27.0 ± 5.5% and −17.2 ± 4.3%, respectively. These data are indicative of an accumulation of fluid in the nasal airways. MRI provides an effective means to monitor changes in the nasal airways which occur as a result of pharmacological treatment.

📜 SIMILAR VOLUMES

A nuclear magnetic resonance investigati
A nuclear magnetic resonance investigation of the upper airways in ferrets. ii. contrast-enhanced imaging to distinguish vascular from other nasal fluids
✍ Nicholas V. Reo; Marise E. Alexander; Rashmi Goel 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 630 KB

## Abstract Proton magnetic resonance imaging (MRI), used in conjunction with the intravascular contrast agent albumin‐(Gd‐DTPA), provides a means to distinguish vascular fluids from other nasal fluids in the upper airways. Ferrets were given an intravenous dose of albumin‐(Gd‐DTPA) followed by an

Investigation of benzimidazoles. III—tra
Investigation of benzimidazoles. III—transmission of the substituent effects in 2-substituted 1-methylbenzimidazoles studied by 13C nuclear magnetic resonance
✍ V. A. Lopyrev; L. I. Larina; T. I. Vakul'skaya; E. F. Shibanova; I. A. Titova; M 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 394 KB

## Abstract The influence of substituents on the ^13^C NMR chemical shifts of 2‐substituted 1‐methylbenzimidazoles has been investigated. The electronic effects of the substituents are transmitted to C‐4 and C‐7 mainly by the resonance mechanism, and to C‐5, C‐6 and __N__‐CH~3~, by approximately eq

Nuclear magnetic resonance investigation
Nuclear magnetic resonance investigation of the interaction of water vapor with sildenafil citrate in the solid state
✍ David C. Apperley; Pat A. Basford; Christopher I. Dallman; Robin K. Harris; Mich 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 1 views

Solid-state carbon-13 ( 13 C) and nitrogen-15 ( 15 N) nuclear magnetic resonance (NMR) have been used to investigate how water interacts with sildenafil citrate. When the humidity is altered, the water concentration in the solid compound changes in a reversible manner. The proportion of occupied sit

Transmission of the substituent effects
Transmission of the substituent effects in 2-substituted benzimidazoles studied by 1H and 13C nuclear magnetic resonance
✍ V. A. Lopyrev; L. I. Larina; T. I. Vakul'skaya; M. F. Larin; O. B. Nefedova; E. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 503 KB

## Abstract The substituent influence on the ^1^H and ^13^C NMR chemical shifts in 2‐substituted benzimidazoles and their anions and cations has been investigated. The transmission of the electronic effects of substituents from C‐2 to C‐5 (6) is approximately 20% less effective than that in the opp

Nuclear magnetic resonance investigation
Nuclear magnetic resonance investigation of the helix to random coil transformation in poly-α-amino acids. I. Poly-L-alanine
✍ James A. Ferretti; Livio Paolillo 📂 Article 📅 1969 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 796 KB

High-resolution nuclear magnetic resonance spectra at 100 MHz and 220 MHz have been obtained on two samples of poly-Galanine of Mering molecular weights (2500 and 42 500) in the chloroform-trifluoroacetic acid system under various conditions of solvent composition, temperature, and polypeptide conce