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A novel Wilms’ tumor

✍ Scribed by Nicole Wagner; Kay-Dietrich Wagner; Mickael Afanetti; Fabien Nevo; Corinne Antignac; Jean-Francois Michiels; Andreas Schedl; Etienne Berard


Publisher
Springer
Year
2008
Tongue
English
Weight
990 KB
Volume
23
Category
Article
ISSN
0931-041X

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Wilms tumor (WT), a sporadic and familial childhood kidney tumor, is genetically heterogeneous. One WT gene, WT1 at 11p13, has been cloned, but only a minority of WTs carry detectable mutations at that locus. WT1 can also be excluded as the predisposition gene in most WT families, implying the exist

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## Abstract Wilms tumor (WT), an embryonic tumor arising from undifferentiated renal mesenchyme, has been a productive model for understanding the role of genes in both tumorigenesis and normal organogenesis. Approximately 2% of WT patients have a family history of WT, and even sporadic WT is thoug

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A 17-month-old black male, who had bilateral Wilms tumor diagnosed nine months earlier, was presented for consideration of further therapy. He was first seen when eight months of age because of a right-sided abdominal mass. There was no hematuria and his blood pressure was normal at that time. The

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