✦ LIBER ✦

A novel tumor-associated antigen expressed in human uterine and ovarian carcinomas

✍ Scribed by Kenzo Sonoda; Manabu Nakashima; Tsunehisa Kaku; Toshiharu Kamura; Hitoo Nakano; Takeshi Watanabe

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 862 KB
Volume: 77
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960415)77:8<1501::aid-cncr12>3.0.co;2-3

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✦ Synopsis

BACKGROUND.

A large number of monoclonal antibodies (MoAhs) against human tumor cells have been generated and it has been shown that these MoAbs are useful tools in the diagnosis and treatment of cancer patients, as well as in the basic investigation of the oncogenesis and characterization of cancer cells.

METHODS.

The 22-1-1 MoAb was established by cell fusion between mouse rnyeloma cells and spleen cells derived from mice immunized with the human uterine cervical adenocarcinoma cell line, SiSo. The tissue distribution and biologic characteristics of the 22-1-1 antigen (Ag) were examined.

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