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A Novel Trypsin-Catalyzed Three-Component Mannich Reaction

✍ Scribed by She-Jie Chai; Yi-Feng Lai; Hui Zheng; Peng-Fei Zhang


Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
149 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

We found that the trypsin from hog pancreas displayed high activity to promote three‐component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate‐to‐excellent yields. The reaction tolerates a great range of substrates and extends the application of trypsin in organic synthesis.


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