A Novel Trypsin-Catalyzed Three-Component Mannich Reaction
β Scribed by She-Jie Chai; Yi-Feng Lai; Hui Zheng; Peng-Fei Zhang
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- German
- Weight
- 149 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0018-019X
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β¦ Synopsis
Abstract
We found that the trypsin from hog pancreas displayed high activity to promote threeβcomponent Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderateβtoβexcellent yields. The reaction tolerates a great range of substrates and extends the application of trypsin in organic synthesis.
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