A novel thioether linker: Chemical synthesis of a HIV-1 protease analogue by thioether ligation

Kinetic properties of HIV-1 protease pro

Kinetic properties of HIV-1 protease produced by total chemical synthesis with cysteine residues replaced by isosteric L-α-amino-n-butyric acid

✍ Douglas A. Bergman; Dianne Alewood; Paul F. Alewood; John L. Andrews; Ross I. Br 📂 Article 📅 1995 🏛 Springer Netherlands 🌐 English ⚖ 608 KB

Human immunodeficiency virus-I protease, produced by total chemical synthesis with the cysteine residues replaced by L-a-amino-n-butyric acid ([Aba 67' 95] HIV-1 PR), has been used extensively for the X-ray crystallographic structural analysis of the enzyme and its complexes utilized in drug design.