## BACKGROUND. Most strategies in cancer immunotherapy are aimed at the induction of a strong cellular immune response against the tumor. Particularly, CD8 + T lymphocytes have been proven in multiple animal models to be critical for the eradication of solid tumors. METHODS. We used a population o
A novel system of artificial antigen-presenting cells efficiently stimulates Flu peptide-specific cytotoxic T cells in vitro
β Scribed by Hui Han; Ji-Run Peng; Peng-Cheng Chen; Lei Gong; Shi-Shi Qiao; Wen-Zhen Wang; Zhu-Qingqing Cui; Xin Yu; Yu-Hua Wei; Xi-Sheng Leng
- Book ID
- 116302054
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 863 KB
- Volume
- 411
- Category
- Article
- ISSN
- 0006-291X
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## Abstract The requirements for the conversion of CD8^+^ memory T cells into effector class I major histocompatibility complex (MHC) K^d^βrestricted cytotoxic T (T~c~) cells __in vitro__ have been studied. Purified CD8^+^splenocytes from influenza A/WSNβprimed BALB/c (Hβ2^d^) mice stimulated with
## Abstract Cytotoxic T lymphocytes (CTL) recognize antigenic peptides presented by major histocompatibility complex class I (MHCβI) molecules on the surface of target cells. Optimal induction of CD8^+^ CTL depends on the amount of relevant peptide/MHCβI complexes and the presence of coβstimulatory