A novel system for mitigation of ectopic transgene expression induced by adenoviral vectors
β Scribed by Reynolds, P N; Holmes, M D; Adachi, Y; Kaliberova, L; Curiel, D T
- Book ID
- 110038971
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 114 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0969-7128
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## Abstract ## Background Recombinant adenoviruses are an established tool for somatic gene transfer to multiple cell types in animals as well as in tissue culture. However, generation of adenoviruses expressing transgenes that are potentially toxic to the host cell line represents a practical pro
## Abstract ## Background Adenoviral vectors have been shown to efficiently transfer DNA into a wide variety of eukaryotic cells __in vitro__ and __in vivo__. However, the therapeutic benefit of this approach is limited by severe side effects as a result of uncontrolled transgene expression. ## M