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A novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle

✍ Scribed by Yoshihiko Murakami; Masayuki Yokoyama; Teruo Okano; Hiroshi Nishida; Yasuko Tomizawa; Masahiro Endo; Hiromi Kurosawa

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
249 KB
Volume
80A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

We prepared a novel tissue‐adhesive hydrogel by using a polymeric micelle consisting of an aldehyde‐terminated poly(ethylene glycol)–poly(D,L‐lactide) (PEG–PLA) block polymer. A Schiff base is chemically formed between the amino groups in a polyallylamine and the aldehyde groups on the surface of polymeric micelles. The hydrogel was formed in ∼2 s when the polymeric micelle solution and polyallylamine solution are mixed in vitro. The hydrogel was rapidly formed in vivo, and it adhered to a tissue surface. Our novel tissue‐adhesive hydrogel creates no risk of infectious contaminations, because it consists of only synthetic materials. Further, PEG and PLA are known to be biocompatible and noncytotoxic. The results obtained in the present study show that a hydrogel prepared by the formation of a Schiff base between aldehyde and amine groups will potentially address the need for novel tissue‐adhesive materials. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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