Synthesis of New Macrocyclic Lactames, Lactones, and Thiolactones. -A new and general method for the synthesis of macrocyclic lactones (II) , lactames (IV), and thiolactones (VI) using the tosyl chloride mediated cyclization of heteroaromatic amino acids is developed. -(YAVOLOVSKII,
A Novel Synthesis of Macrocyclic Lactones
✍ Scribed by Prof. Dr. Hans Jürgen Bestmann; Rainer Schobert
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 300 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0044-8249
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Decarboxylative Photocyclization: Synthesis of Benzopyrrolizidines and Macrocyclic Lactones. -Irradiation of potassium salts of the amino acid derivatives (I), (VII), and (IX) leads to the cyclization products (II), (VIII), and (X). Product (VIII) cyclizes with high cis diastereoselectivity, wherea
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