✦ LIBER ✦

A novel synthesis of EGFR-tyrosine-kinase inhibitors with 4-(indol-3-yl)quinazoline structure

✍ Scribed by Anja Lüth; Werner Löwe

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 313 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450311

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✦ Synopsis

Abstract

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The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell‐surface receptors. A new synthetic pathway of 4‐(indol‐3‐yl)quinazolines 15 and 16 is described using cross coupling reactions with quinazoline‐ and indole moieties. The synthesized compound 15 is a new dual and high potent EGFR‐ and HER‐2‐tyrosine kinase inhibitor with excellent cytotoxic properties at different cell lines. Furthermore this substance class shows remarkably strong fluorescence.

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