✦ LIBER ✦

A novel synthesis of (+)-duocarmycin SA

✍ Scribed by Yasumichi Fukuda; Shiro Terashima

Book ID: 104258025
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 139 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01716-4

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✦ Synopsis

The title synthesis was achieved in eight steps from (S)-5-aminoindoline (S)-4 by a method featuring sequential dehydrogenation, double bond isomerization, and oxidative cyclization of (S)-5-[(I-methoxycarbonylethyl)amino]indoline 5 as the key steps. The sequential reaction was effected by using MnO2-Pd(OAc)2 as the oxidizing agent in the presence of an acid catalyst.

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