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A novel surface-active peptide derivative exhibits in vitro inhibition of platelet aggregation

โœ Scribed by C.V. Ramesh; R. Jayakumar; R. Puvanakrishnan

Book ID
117409272
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
178 KB
Volume
19
Category
Article
ISSN
0196-9781

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The mycotoxin ochratoxin A (OA) consists of 5-chloro-3-methyl-3,4-dihydro-8-hydroxyisocoumarin moiety linked by an amide bond to p-Lphenylalanine. When added to washed rat platelets in vitro, OA caused a dose-dependent inhibition of aggregation induced by agonists such as adenosine diphosphate (ADP)