✦ LIBER ✦
A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindolines via AlEt3-promoted Tandem Reductive Rearrangement of α-Hydroxy Epoxides
✍ Scribed by Shuan-Hu Gao; Yan-Xing Jia; Xue-Zhi Zhao; Yong-Qiang Tu
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 51 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0256-7660
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✦ Synopsis
Abstract
The fully substituted cyclopentenedione core of madindoline A (1) and B (2) as potent and selective inhibitor of IL‐6 has been synthesized efficiently. The quaternary carbon center C‐2′ was constructed on the basis of a newly developed AlEt~3~‐promoted tandem reductive rearrangement of α‐hydroxy epoxides.