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A Novel Strategy for the Construction of Functionalized 1,5- Benzodiazepines via a Tandem Conjugated Addition/Cyclization Process

โœ Scribed by Jian Li; Shaoyu Li; Chunju Li; Yuejin Liu; Xueshun Jia


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
140 KB
Volume
352
Category
Article
ISSN
1615-4150

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ChemInform Abstract: Stereochemistry. Pa
โœ I. N. N. NAMBOOTHIRI; A. HASSNER; H. E. GOTTLIEB ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 32 KB ๐Ÿ‘ 1 views

Strategy for the Construction of Functionalized Five-and Six-Membered Carbocycles. -Conjugate addition of the Grignard reagents (II) and (IV) to the nitro olefins (I) leads to the intermediate formation of nitronates, which are trapped as silyl nitronates and subsequently cyclized by intramolecular