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A novel strategy for rapid and efficient isolation of human tumor-specific CD4+ and CD8+ T-cell clones

✍ Scribed by Seung-Tae Lee; Shujuan Liu; Laszlo Radvanyi; Pariya Sukhumalchandra; Jeffrey J. Molldrem; Eric D. Wieder; Patrick Hwu; Yong-Jun Liu; Larry W. Kwak; Gregory Lizée; Sattva S. Neelapu


Book ID
113717451
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
889 KB
Volume
331
Category
Article
ISSN
0022-1759

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## Abstract Spontaneous tumors frequently express antigens that can be recognized by the immune system but nevertheless manage to evade immune surveillance. To better understand the mechanism of evasion, we followed CD8 and CD4 T cells reacting against a subcutaneously growing tumor, modified to ex