A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity

Inhibition of cyclin-dependent kinases 2

Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (−)-epigallocatechin-3-gallate

✍ Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chieh-Fu Chen; Jen-Kun Lin 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 2 views

Ϫ)-Epigallocatechin-3-gallate (EGCG) potently inhibits cell proliferation and suppresses tumor growth both in vitro and vivo, but little is known regarding the cell cycle regulatory proteins mediating these effects. This study investigated the effects of EGCG and other catechins on the cell cycle pr