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A novel stereoselective synthesis of the ring AB podocarpate system

โœ Scribed by Ling Lu; Richard K. Shoemaker; Desmond M.S. Wheeler

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
209 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A new way of stereoselectively synthesizing rings A and B of podocarpate has been developed; the correct stereochemistry at C, is obtained during a cyclization linking Cz to C,. Although members of the family of norditerpenoid dilactones that includes inumakilactones, podolactones, nagilactones, podolide, and the sellowins,' (e.g.1 ), show interesting biological activities,' they have attracted little attention from synthetic chemists. 3 Apparently only four syntheses have been completed: that of nagilactone F from podocarpic acid& and three syntheses of the related mold metabolite LL-Z1271a4.

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