A novel statistical model for finding patterns in cell-cycle transcription data

A consistent pattern of RIN1 rearrangeme

A consistent pattern of RIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification

✍ Michele I. Shuster; Limin Han; Michelle M. Le Beau; Elizabeth Davis; Mark Sawick 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 2 views

Gene amplification is a common feature of tumors. Overexpression of some amplified genes plays a role in tumor progression. Gene amplification can occur either extrachromosomally as double-minute chromosomes (dmin) or intrachromosomally in the form of homogeneously staining regions (hsrs). Approxima