A novel spin-labeled amino acid derivative for use in peptide synthesis: (9-fluorenylmethyloxycarbonyl)-2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid
โ Scribed by Marchetto, Reinaldo; Schreier, Shirley; Nakaie, Clovis R.
- Book ID
- 111927314
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 218 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Amination of 3-carboxymethyl-1-oxyl-2,2,6,6-tetramethyl-4-piperidone with (R)-a-methylbenzylamine, NaBH 3 CN reduction of the resulting enamine and removal of the chiral auxiliary from the separated diastereoisomers, led to enantiomerically pure (3S,4S) and (3R,4R) methyl 4-amino-1-oxyl-2,2,6,6-tetr
## Abstract __N__โ[1โ(4โ(4โfluorophenyl)โ2,6โdioxocyclohexylidene)ethyl] (Fde) protected amino acids have been prepared and applied in solidโphase peptide synthesis monitored by gelโphase ^19^F NMR spectroscopy. The Fde protective group could be cleaved with 2% hydrazine or 5% hydroxylamine solutio