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A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization

✍ Scribed by Craig Jamieson; Robert A. Campbell; Iain A. Cumming; Kevin J. Gillen; Jonathan Gillespie; Bert Kazemier; Michael Kiczun; Yvonne Lamont; Amanda J. Lyons; John K.F. Maclean; Frederic Martin; Elizabeth M. Moir; John A. Morrow; John Pantling; Zoran Rankovic; Lynn Smith


Book ID
104004787
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
858 KB
Volume
20
Category
Article
ISSN
0960-894X

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πŸ“œ SIMILAR VOLUMES


Hit-to-lead optimization of a series of
✍ Anette Graven Sams; Gitte KobberΓΈe Mikkelsen; Mogens Larsen; Lars Torup; Lise TΓΈ πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 475 KB

Chart 1. Structures and hA 2A and hA 1 binding affinities of istradefylline (KW-6002, 1), preladenant (SCH-420814, 2) and HTS hit 3.