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A Novel Sensitive Colorimetric Assay for Visual Detection of Solid-Phase Bound Amines

✍ Scribed by Annemieke Madder; Nadia Farcy; Noel G. C. Hosten; Hilde De Muynck; Pierre J. De Clercq; John Barry; Anthony P. Davis

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 914 KB
Volume: 1999
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(199911)1999:11<2787::aid-ejoc2787>3.0.co;2-d

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✦ Synopsis

A new simple and efficient method for the detection of direct coloring of the beads. A specific feature of the assay resides in the possibility of detection of sterically hindered incomplete coupling reactions during solid-phase peptide synthesis is decribed. Using p-nitrophenyl ester 1 (NF31), primary amines. free amino groups can be visually detected on the resin by Table . [6Ϫ15] The methods can be subdivided into three catfollowing: the azo unit is reasonably chemically inert (at

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