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A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome

✍ Scribed by Kenichiro Yamamura; Jun Muneuchi; Kiyoshi Uike; Kazuyuki Ikeda; Hirosuke Inoue; Yasushi Takahata; Yuichi Shiokawa; Yukako Yoshikane; Takeru Makiyama; Minoru Horie; Toshiro Hara

Book ID
116548195
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
340 KB
Volume
145
Category
Article
ISSN
0167-5273

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Identification of a new SCN5A mutation,
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The long QT syndrome (LQT) is an inherited cardiac disorder that can cause sudden cardiac death among apparently healthy young individuals due to malignant ventricular arrhythmias. LQT was found to be caused by mutations in four genes LQT1, LQT2, LQT3 and LQT5, and linkage was reported for an additi

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