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A NOVEL ROUTE TO N-(BENZOTRIAZOL-1-YLMETHYL)AMIDES

✍ Scribed by Katritzky, Alan R.; Galuszka, Barbara; Zhang, Yongmin; Rachwal, Stanislaw


Book ID
127341086
Publisher
Taylor and Francis Group
Year
1992
Tongue
English
Weight
257 KB
Volume
24
Category
Article
ISSN
0030-4948

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A novel selective route to 1-substituted
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## Abstract 1‐Methylbenzotriazole (2a) is lithiated readily with butyllithium or LDA at the methyl group to 4 and the subsequent reaction with various electrophiles provides 1‐substituted benzotriazoles 5. Other 1‐(__n__‐alkyl)benzotriazoles 2 also undergo lithiation with LDA, the carbanions can be