A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells

✍ Scribed by Simhadri, Vijaya Lakshmi (author);Hansen, Hinrich P. (author);Simhadri, Venkateswara R. (author);Reiners, Katrin S. (author);Bessler, Martina (author);Engert, Andreas (author);Von Strandmann, Elke Pogge (author)

• Book ID: 125513143
• Publisher: Walter de Gruyter GmbH & Co. KG
• Year: 2012
• Tongue: English
• Weight: 561 KB
• Volume: 393
• Category: Article
• ISSN: 1431-6730
• DOI: 10.1515/BC-2011-213

✦ Synopsis

Abstract

The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-κB-dependent release of TNF-α/IFN-γ. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.