𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A novel ring transformation of 5-azidothiazoles

✍ Scribed by Erik Ceulemans; Leonard K. Dyall; Wim Dehaen

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
516 KB
Volume
55
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

The 4-oxoalkyl-and 4-iminoaikyl-5-azidothiazoles undergo a ring transformation with nitrogen loss at relatively low temperatures to afford 4-cyanooxazoles and 4-cyanoimidazoles, respectively. The mechamsm, wMch ts thought to revolve a ring openmg-rmg closure process, is discussed.

πŸ“œ SIMILAR VOLUMES

A novel ring transformation of 5-nitrour
A novel ring transformation of 5-nitrouracils into 5-carbamoyluracils via the retro-michael reaction
✍ Kosaku Hirota; Yukio Kitade; Shigeo Senda πŸ“‚ Article πŸ“… 1981 πŸ› Elsevier Science 🌐 French βš– 118 KB

Treatment of 1,3-disubstituted 5-nitrouracils(5) with malonamide in ethanolic sodium ethoxide caused a ring transformation to afford l-substituted 5-carbamoyluracils(6) in good yields. Reactions of uracil derivatives with various nucleophiles have been extensively investigated in connection with bio