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A novel radical reaction of alkyl xantates useful for the selective substitution of heteroaromatic bases

โœ Scribed by Fausta Coppa; Francesca Fontaria; Francesco Minisci; Giuseppe Pianese; Paola Tortoreto; Lihua Zhao


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
160 KB
Volume
33
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Cyclohexyl radical is generated from cyciohexyldithiocarbonate and benzoyl peroxide. The radical source is used for the alkylation of heteroaromatic bases.


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## Abstract A highly selective method for the synthesis of Nโ€9 alkylated purine nucleoside derivatives __via__ an intermolecular hydrogen abstraction reaction between nitrogen radicals in purine rings and alkyl ethers was developed. Novel purine nucleoside derivatives were obtained with good to hig