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A novel racemization mechanism for the α-hydroxy ketone moiety(C9-position) of optically active anthracyclinone derivatives

✍ Scribed by Shiro Terashima; Katsumi Tamoto


Book ID
104217438
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
264 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis


Sumnary-

The facile pcid-catalyzed racemization of optically active anthracyclinone derivatives((S)(+)-la) was found to proceed through the ring-expanded seven-membered a-hydroxy ketones($ and/or 2 for (S)(+)-1~) by subjecting various plausible intermediates to the racemization condition.