✦ LIBER ✦
A novel pseudo-seven-component diastereoselective synthesis of λ5-phosphanylidene bis(2,5-dioxotetrahydro-1H-pyrrole-3-carboxylates) via binucleophilic systems
✍ Scribed by Abdolali Alizadeh; Sadegh Rostamnia; Long-Guan Zhu
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 444 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The unusual 1:2 intermediate, generated by the addition of triphenylphosphine (TPP) to dialkyl acetylenedicarboxylates (DAAD) was trapped during the reaction of a Ph 3 P/RN = C/DMAD binucleophilic system with TFA as an initial proton source in a pseudo-seven-component (7-CR) diastereoselective reaction to give k 5 -phosphanylidene bis(2,5-dioxotetrahydro-1H-pyrrole-3-carboxylates) with three stereogenic centers and a phosphorane group in good yields.