A novel process for the synthesis of 3,5-diaryl-1,2,4-thiadiazoles from aryl nitriles
โ Scribed by Noei, Jalil; Khosropour, Ahmad Reza
- Book ID
- 118042316
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 286 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
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## Abstract An efficient and practical procedure for direct synthesis of 3,5โdiarylโ1,2,4โthiadiazoles by thioamides with 2,4,6โtrichloroโ1,3,5โtriazine (TCT) and dimethylsulfoxide using 1โbutylโ3โmethylimidazolium tetrafluoroborate as an ecoโfriendly reaction medium under ambient temperature is de
The reaction of 3,6-diaryl-1,2,4,5-tetrazines and 2-aryl substituted acetonitriles, under basic conditions, leads unexpectedly to 3,5-diaryl-(NH)-1,2,4-triazoles in moderate yields. A mechanism is proposed.