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A novel polymeric conjugate carrying two different anticancer drugs

✍ Scribed by Song, Soo-Chang; Lee, Chong Ok; Sohn, Youn Soo

Book ID: 101227628
Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 65 KB
Volume: 48
Category: Article
ISSN: 0959-8103
DOI: 10.1002/(sici)1097-0126(199908)48:8<627::aid-pi241>3.0.co;2-q

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✦ Synopsis

Two different antitumour chemotherapeutic agents, doxorubicin and (dach)platinum(II) complex (dach = trans(AE)-1,2-diaminocyclohexane) were introduced into poly(organophosphazene) using L-glutamic acid as a spacer. The resultant polymeric conjugates exhibited high in vivo antitumour activity which increased with increasing content of (dach)platinum(II) in the conjugates. The polymeric conjugate bearing 12.3 mol% of doxorubicin and 47.6 mol% of (dach)platinum(II) has shown the highest antitumour activity, which is higher than any one alone of cisplatin, carboplatin, or doxorubicin.

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