## Abstract The E5 oncoprotein of human papillomavirus type 16 downregulates surface MHC Class I and interacts with the heavy chain of the MHC complex __via__ the first hydrophobic domain, believed to form the first helical transmembrane region (TM1) of E5. TM1 contains 4 equally spaced diβleucine
β¦ LIBER β¦
A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein
β Scribed by Susanne Dymalla; Martin Scheffner; Elvira Weber; Peter Sehr; Claudia Lohrey; Felix Hoppe-Seyler; Karin Hoppe-Seyler
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 582 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0946-2716
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## Abstract Human papillomavirus typeβ16 (HPVβ16) is an epitheliotropic DNA tumor virus associated with the development of cervical carcinoma. The expression of HPVβ16 early genes is driven by a cellβtypeβspecific enhancer located in the long control region of the viral genome. We identified an ele