A novel one-pot synthesis of 1,2,4-triazole-3,5-diamine derivatives from isothiocyanates and mono-substituted hydrazines

✍ Scribed by Chunjian Liu; Edwin J. Iwanowicz

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 127 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02871-x

✦ Synopsis

1,2,4-Triazole-3,5-diamine derivatives were synthesized in moderate to high yields in one-pot reaction from the corresponding isothiocyanates, mono-substituted hydrazines, and sodium hydrogencyanamide, in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. Typically, two target compounds were obtained, but high regioselectivities to one isomer were observed when aromatic and sterically bulky hydrazines were used. A number of examples with a detailed representative procedure are given.