A novel and efficient domino reaction fo
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Sorour Ramezanpour; Mehri Seyed Hashtroudi; Hamid Reza Bijanzadeh; Saeed Balalai
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Article
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2008
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Elsevier Science
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French
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A novel and efficient protocol is developed for the synthesis of various spiro-2-amino pyrimidinones via the three-component condensation of alkyl cyanoacetates, guanidinium carbonate and N-substituted 4-piperidinones in ethanol at reflux. High yields, neutral conditions, and short reaction times ar