A novel one-pot and efficient procedure for the synthesis of 3H-spiro[isobenzofuran-1,6′-pyrrolo[2,3-d]pyrimidine]-2′,3,4′,5′-tetraones
✍ Scribed by Mohammad Reza Mohammadizadeh; Mojtaba Bahramzadeh; S. Zainabkhatoon Taghavi
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 728 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A novel and practical one-pot procedure is described for the preparation of several new of 3H-spiro[isobenzofuran-1,6 0 -pyrrolo[2,3-d]pyrimidine]-2 0 ,3,4 0 ,5 0 -tetraones based on the addition reaction of ninhydrin and 6-aminouracils followed by oxidative cleavage of their corresponding dihydroxyindenopyrrolopyr imidines.
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## Abstract A novel one‐pot procedure for preparation of some new condensed pyrido[2,3‐__d__]pyrimidine(1__H__,3__H__)‐2,4‐diones based on condensation of ninhydrin, alkyl cyanoacetate, and 6‐aminouracil derivatives has been reported. The reactions were carried out in refluxed ethanol and were comp
Cascade assembly of N,N 0 -dialkylbarbituric acids and aldehydes in the presence of bromine leads to the selective and efficient formation of substituted 1,5-dihydro-2H,2 0 H-spiro(furo[2,3-d]pyrimidine-6,5 0pyrimidine)-2,2 0 ,4,4 0 ,6 0 -(1 0 H,3H,3 0 H)-pentones in 70-88% yields via a complex casc