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A Novel Oligodeoxynucleotide Inhibitor of Thrombin. II. Pharmacokinetics in the Cynomolgus Monkey

✍ Scribed by William A. Lee; James A. Fishback; Jeng-Pyng Shaw; Louis C. Bock; Linda C. Griffin; Kenneth C. Cundy


Book ID
110347034
Publisher
Springer US
Year
1995
Tongue
English
Weight
912 KB
Volume
12
Category
Article
ISSN
0724-8741

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The intravenous pharmacokinetic disposition of the novel, atypical anxiolytic CGS 9896 was studied in six cynomolgus monkeys. CGS 9896 was infused at dose levels of approximately 60, 120, and 240 ~tg/h/kg for a duration of 12 h, resulting in steady-state plasma concentrations averaging 38.4, 51.8, a